#6910 PREDICTORS OF KIDNEY FUNCTION DECLINE IN LIVING KIDNEY TRANSPLANTATION DONORS

Abstract Background and Aims After nephrectomy kidney transplant donors lose 50% of their renal mass. Shortage long waiting list for deceased donor transplantation expanded the living criteria. The aim this study to identify pretransplant related factors associated with function decline. Method We retrospectively studied LDKT from one center in period 2013 -2022. Data was retrieved medical history charts national electronic database system. Demographic characteristics as age, gender relation recipient, patients preference donate higher measured split GFR, presence diabetes, hypertension, hyperlipidemia BMI >30kg/m2 were analysed. Estimated GFR by CKD EPI notified prior donation, two years afterwards. In a multivariate regression analysis reduction ratio explored dependent variable. Results 121 donors. average age at time 59.18 ± 10.99 years. Donors’ eGFR 91.53 18.62 mL/min. Donor's significantly correlated (p < 0.0001, r=r−0.529). Male 37 (30%), 11 (9%) unrelated recipients, 9(7%) had BMI>30, 17 (14%) 53 (44%) hypertension 5 (4% hyperlipidemia), 65 (52%) more then comorbidity combined. Eight (7%) decided better kidney. declined 68.17±18.62 ml/min first 66.01±21.29 second year. RR 24.53 20.60 % 27.62±18.76% raised on yearly bases, respectively. univariate declination year BMI>30 kg/m2 (β=0.318, P = .003). At diabetes emerged worsening factor (β=0.227, .034) kept its significance (β=0.426, .000). All other parameters showed no significant associations remained most powerful predictor 12 months eGFR. Conclusion Patients especially obesity are risk rapid decline after donation. Careful assessment donation should weight risks.